Repeat dosing of rocuronium 1.2 mg kg −1 after reversal of neuromuscular block by sugammadex 4.0 mg kg −1 in anaesthetized healthy volunteers: a modelling-based pilot study
نویسندگان
چکیده
منابع مشابه
Safety and tolerability of single intravenous doses of sugammadex administered simultaneously with rocuronium or vecuronium in healthy volunteers.
BACKGROUND Sugammadex rapidly reverses rocuronium- and vecuronium-induced neuromuscular block. To investigate the effect of combination of sugammadex and rocuronium or vecuronium on QT interval, it would be preferable to avoid the interference of anaesthesia. Therefore, this pilot study was performed to investigate the safety, tolerability, and plasma pharmacokinetics of single i.v. doses of su...
متن کاملCardiovascular effects of an intubating dose of rocuronium 0.6 mg kg-1 in anaesthetized patients, paralysed with vecuronium.
We have studied, in adult patients, ASA I-II, the cardiovascular effects of an intubating dose of rocuronium 0.6 mg kg-1. After induction, patients were paralysed with vecuronium and the trachea intubated. Heart rate (HR) and non-invasive mean arterial pressure (MAP) were measured every 1 min. After stabilization of HR and MAP, defined as < 3% change over three measurements, rocuronium (n = 20)...
متن کاملSugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey.
BACKGROUND Binding of the steroidal molecule of rocuronium by a cyclodextrin is a new concept for reversal of neuromuscular block. The present study evaluated the ability of Sugammadex Org 25969, a synthetic gamma-cyclodextrin derivative, to reverse constant neuromuscular block of about 90% induced by rocuronium or the non-steroidal neuromuscular blocking drugs, mivacurium or atracurium, in the...
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The pharmacokinetics of trimethoprim-sulfamethoxazole were studied in 12 healthy adult subjects receiving trimethoprim at 20 mg/kg of body weight per day and sulfamethoxazole at 100 mg/kg/day, which is the conventional dose for treating Pneumocystis carinii pneumonia (PCP). Daily doses were evenly divided and orally administered every 6 h for 3 days. Trimethoprim, sulfamethoxazole, and N4-acety...
متن کاملPlasma levels of intranasal midazolam at 0.4 mg/kg and 0.2 mg/kg doses.
Five young adult Rhesus monkeys were included in this study. The weight of the animals ranged from 3.4 to 4.0 kg, with a mean of 3.6 kg. Each animal was restrained and anesthetized with ketamine HC1 at 25 mg/kg IM. An intravenous fluid of 5% dextrose and water with 1/4 normal saline was initiated and profused at a maintenance rate. Each monkey received intranasal midazolam (VersedTM, Roche Phar...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2010
ISSN: 0007-0912
DOI: 10.1093/bja/aeq167